Journal: Materials

Article Title: Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

doi: 10.3390/ma11112081

Figure Lengend Snippet: Synopsis of the bio-functionality realm of cation-substituted hydroxyapatites.

Article Snippet: Ce (3+) , Powder Coating , 4–20 , ○ Induces the in vitro formation of bone-like apatite in SBF; ○ In vitro cytocompatibility with L929 (for Ce-HA dose <100 μg mL −1 ) and MC3T3-E1 cell lines; ○ Cytotoxicity on pulmonary adenocarcinoma (A549) cells in Ce0.1HA, but improvement of cell viability in conjunction with strontium [ ]; ○ Antibacterial effect against S. aureus (ATCC 6538), Lactobacillus (ATCC 393), E. coli (8099), and P. aeruginosa ; enhanced zone inhibition is achieved for Gram-negative E. coli with respect to Gram-positive S. aureus . , [ , , , , , ] .

Techniques: In Vitro, Isolation, In Vivo, Animal Model, Adsorption, Concentration Assay, Modification, Dissolution, Activity Assay, Staining, Bacteria, Control, Transformation Assay

Journal: Pharmaceutics

Article Title: Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

doi: 10.3390/pharmaceutics12010029

Figure Lengend Snippet: Lipid-based systems for delivery of amphotericin B currently under development.

Article Snippet: Cochleates (CAmB) , Oral , 407.3 ± 233.8 , , Soy lecithin (enriched with 50% w / w PS-CaCl 2 ): AmB (1:10 molar ratio). Aqueous-aqueous hydrogel binary system. , Oral CAmB + flucytosine more effective than oral fluconazole against C. neoformans H99 (ATCC 208821) in a murine model of cryptococcal meningoencephalitis without toxic side effects. Fluorescence imaging demonstrated brain transport and accumulation of CAmB. Oral CAmB (25 mg/kg/day) and AmB-DOC (5 mg/kg/day i.p.) plus oral flucytosine (250 mg/kg/day) for 3 weeks had similar efficacy and immunological profile in treated mice. , [ , ] .

Techniques: Formulation, Conjugation Assay, Permeability, In Vitro, Activity Assay, Produced, MTT Assay, In Vivo, Concentration Assay, Spectroscopy, Shear, Liposomes, Modification, Dispersion, Injection, Incubation, Saline, Sonication, Infection, Solubility, Encapsulation, Homogenization, Titration, Ex Vivo, Viscosity, Inhibition, Diffusion-based Assay, Emulsion, Clinical Proteomics, Fluorescence, Imaging, Adjuvant, Expressing, RNA Expression, Solvent, Control, Histopathology, Polymer, Evaporation, Emulsification, Eye Drops

Journal: Pharmaceutics

Article Title: Lipid Systems for the Delivery of Amphotericin B in Antifungal Therapy

doi: 10.3390/pharmaceutics12010029

Figure Lengend Snippet: Recently completed, on-going and expected clinical trials evaluating amphotericin B (AmB) safety and efficacy against antifungal and antiparasitic diseases.

Article Snippet: Cochleates (CAmB) , Oral , 407.3 ± 233.8 , , Soy lecithin (enriched with 50% w / w PS-CaCl 2 ): AmB (1:10 molar ratio). Aqueous-aqueous hydrogel binary system. , Oral CAmB + flucytosine more effective than oral fluconazole against C. neoformans H99 (ATCC 208821) in a murine model of cryptococcal meningoencephalitis without toxic side effects. Fluorescence imaging demonstrated brain transport and accumulation of CAmB. Oral CAmB (25 mg/kg/day) and AmB-DOC (5 mg/kg/day i.p.) plus oral flucytosine (250 mg/kg/day) for 3 weeks had similar efficacy and immunological profile in treated mice. , [ , ] .

Techniques: Clinical Proteomics, Cream, Aerosol, Saline, Capsules, Injection

Journal: Metabolites

Article Title: Antioxidant and Antibacterial Capacities of Origanum vulgare L. Essential Oil from the Arid Andean Region of Chile and its Chemical Characterization by GC-MS

doi: 10.3390/metabo10100414

Figure Lengend Snippet: ( a ) Inhibitory activity (mm) of O. vulgare essential oil against pathogens and five phytopathogenic bacteria. (■) oregano; ( ■ ) kanamycin positive control. ( b ) Paper disk diffusion assay of oregano essential oil against Escherichia coli . Disk O: oregano oil; disk +: kanamycin positive control; disk −: ethanol negative control.

Article Snippet: Oregano oil was used to determine antibacterial activity against the human pathogenic bacteria Escherichia coli (ATCC 23716), Pseudomonas aeruginosa (ATCC 19429), Salmonella enterica (ATCC 13311), Bacillus subtilis (ATCC 6051), and Staphylococcus aureus (ATCC 29737); and the phytopathogenic bacteria Erwinia rhapontici (MK883065), Pseudomonas syringae (MF547632), Pantoea agglomerans (MK883087), Agrobacterium tumefaciens (ATCC 19358), and Xanthomonas campestris (MH885473).

Techniques: Activity Assay, Bacteria, Positive Control, Diffusion-based Assay, Negative Control

Journal: Metabolites

Article Title: Antioxidant and Antibacterial Capacities of Origanum vulgare L. Essential Oil from the Arid Andean Region of Chile and its Chemical Characterization by GC-MS

doi: 10.3390/metabo10100414

Figure Lengend Snippet: Antibacterial activity of Origanum vulgare essential oil from Putre, Chile.

Article Snippet: Oregano oil was used to determine antibacterial activity against the human pathogenic bacteria Escherichia coli (ATCC 23716), Pseudomonas aeruginosa (ATCC 19429), Salmonella enterica (ATCC 13311), Bacillus subtilis (ATCC 6051), and Staphylococcus aureus (ATCC 29737); and the phytopathogenic bacteria Erwinia rhapontici (MK883065), Pseudomonas syringae (MF547632), Pantoea agglomerans (MK883087), Agrobacterium tumefaciens (ATCC 19358), and Xanthomonas campestris (MH885473).

Techniques: Activity Assay